靶标详情

快速索引

1.General Information
2.Gene Ontology
3.KEGG pathways
4.Sequence
5.Pfam domains
6.Database Cross reference
7.Reference
8.Linked

General Information

ID	UD2B4_HUMAN
Name	UDP-glucuronosyltransferase 2B4
Synonyms	[UDPGT, Hyodeoxycholic acid, HLUG25, UDPGTh-1]
Function classification	Enzyme
Gene Family	UDP-glucuronosyl/UDP-glucosyltransferase
Taxonomy	Homo sapiens
Status

Gene Ontology

GO:0006805	xenobiotic metabolic process	BP
GO:0006711	estrogen catabolic process	BP
GO:0016021	integral to membrane	CC
GO:0005789	endoplasmic reticulum membrane	CC
GO:0005792	microsome	CC
GO:0015020	glucuronosyltransferase activity	MF

KEGG pathways

hsa00830	Retinol metabolism - Homo sapiens (human)
hsa00150	Androgen and estrogen metabolism - Homo sapiens (human)
hsa00860	Porphyrin and chlorophyll metabolism - Homo sapiens (human)
hsa00980	Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
hsa00983	Drug metabolism - other enzymes - Homo sapiens (human)
hsa00982	Drug metabolism - cytochrome P450 - Homo sapiens (human)
hsa00040	Pentose and glucuronate interconversions - Homo sapiens (human)
hsa00500	Starch and sucrose metabolism - Homo sapiens (human)

Sequence

MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADI

Pfam domains

PF00201

UDP-glucoronosyl and UDP-glucosyl transferase

Database Cross Reference

Entrez Gene	UGT2B4
Ensembl Gene	ENSG00000156096
GeneCards	GC04M070394
Unigene	Hs.285887
RefSeq	NP_066962.2
PharmGKB	PA360

Reference

3109396	Jackson M.R., McCarthy L.R., Harding D., Wilson S., Coughtrie M.W.H., Burchell B.	"Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA."	Biochem. J. 242:581-588(1987).
8333863	Jin C.-J., Miners J.O., Lillywhite K.J., McKenzie P.I.	"cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily."	Biochem. Biophys. Res. Commun. 194:496-503(1993).
10376768	Levesque E., Beaulieu M., Hum D.W., Belanger A.	"Characterization and substrate specificity of UGT2B4 (E458): a UDP- glucuronosyltransferase encoded by a polymorphic gene."	Pharmacogenetics 9:207-216(1999).
15489334	The MGC Project Team	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."	Genome Res. 14:2121-2127(2004).

Linked