靶标详情

快速索引

1.General Information
2.Gene Ontology
3.KEGG pathways
4.Sequence
5.Pfam domains
6.Database Cross reference
7.Reference
8.Linked

General Information

ID	IL13_HUMAN
Name	Interleukin-13
Synonyms	[IL-13]
Function classification
Gene Family	Interleukin-4/interleukin-13
Taxonomy	Homo sapiens
Status

Gene Ontology

GO:0007267	cell-cell signaling	BP
GO:0006928	cell motion	BP
GO:0007165	signal transduction	BP
GO:0006954	inflammatory response	BP
GO:0006955	immune response	BP
GO:0005625	soluble fraction	CC
GO:0005615	extracellular space	CC
GO:0005144	interleukin-13 receptor binding	MF
GO:0005125	cytokine activity	MF
GO:0004871	signal transducer activity	MF

KEGG pathways

Sequence

MALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

Pfam domains

PF03487

Interleukin-13

Database Cross Reference

Entrez Gene
Ensembl Gene	ENSG00000169194
GeneCards	GC05P132021
Unigene	Hs.845
RefSeq
PharmGKB	PA199

Reference

8096327	Minty A.J., Chalon P., Derocq J.-M., Dumont X., Guillemot J.-C., Kaghad M., Labit C., Leplatois P., Liauzun P., Miloux B., Minty C., Casellas P., Loison G., Lupker J., Shire D., Ferrara P., Caput D.	"Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses."	Nature 362:248-250(1993).
8097324	McKenzie A.N., Culpepper J.A., Waal Malefyt R., Briere F., Punnonen J., Aversa G., Sato A., Dang W., Cocks B.G., Menon S., de Vries J.E., Banchereau J., Zurawski G.R.	"Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function."	Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993).
7721105	Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.	"Tandem arrangement of human genes for interleukin-4 and interleukin- 13: resemblance in their organization."	Gene 155:277-281(1995).
8605348	Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D., McGurn M., Gibson C., Lewis D.B.	"Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."	Blood 87:3316-3326(1996).
15372022	Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.	"The DNA sequence and comparative analysis of human chromosome 5."	Nature 431:268-274(2004).
7530359	Bamborough P., Duncan D., Richards W.G.	"Predictive modelling of the 3-D structure of interleukin-13."	Protein Eng. 7:1077-1082(1994).
10699178	Heinzmann A., Mao X.-Q., Akaiwa M., Kreomer R.T., Gao P.-S., Ohshima K., Umeshita R., Abe Y., Braun S., Yamashita T., Roberts M.H., Sugimoto R., Arima K., Arinobu Y., Yu B., Kruse S., Enomoto T., Dake Y., Kawai M., Shimazu S., Sasaki S., Adra C.N., Kitaic	"Genetic variants of IL-13 signalling and human asthma and atopy."	Hum. Mol. Genet. 9:549-559(2000).
11588017	Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.	"Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."	Am. J. Respir. Cell Mol. Biol. 25:377-384(2001).
12928861	Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W., Yu L.-S.	"A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."	Hum. Genet. 113:387-390(2003).

Linked