靶标详情

快速索引

1.General Information
2.Gene Ontology
3.KEGG pathways
4.Sequence
5.Pfam domains
6.Database Cross reference
7.Reference
8.Linked

General Information

ID	IBP2_HUMAN
Name	Insulin-like growth factor-binding protein 2
Synonyms	[IGF-binding protein 2, IGFBP-2, IBP-2]
Function classification
Gene Family	Insulin-like growth factor binding protein
Taxonomy	Homo sapiens
Status

Gene Ontology

GO:0001558	regulation of cell growth	BP
GO:0005520	insulin-like growth factor binding	MF

KEGG pathways

Sequence

MLPRVGCPALPLPPPPLLPLLPLLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEH

Pfam domains

PF00219

Insulin-like growth factor binding protein

Database Cross Reference

Entrez Gene	IGFBP2
Ensembl Gene	ENSG00000115457
GeneCards	GC02P217206
Unigene	Hs.438102
RefSeq	NP_000588.2
PharmGKB	PA29704

Reference

2479552	Binkert C., Landwehr J., Mary J.L., Schwander J., Heinrich G.	"Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)."	EMBO J. 8:2497-2502(1989).
1697583	Zapf J., Kiefer M., Merryweather J., Musiarz F., Bauer D., Born W., Fischer J.A., Froesch E.R.	"Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia."	J. Biol. Chem. 265:14892-14898(1990).
1712312	Agarwal N., Hsieh C.L., Sills D., Swaroop M., Desai B., Francke U., Swaroop A.	"Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)."	Exp. Eye Res. 52:549-561(1991).
1710112	Ehrenborg E., Vilhelmsdotter S., Bajalica S., Larsson C., Sterm I., Koch J., Brondum-Nielsen K., Luthman H.	"Structure and localization of the human insulin-like growth factor- binding protein 2 gene."	Biochem. Biophys. Res. Commun. 176:1250-1255(1991).
1376411	Binkert C., Margot J.B., Landwehr J., Heinrich G., Schwander J.	"Structure of the human insulin-like growth factor binding protein-2 gene."	Mol. Endocrinol. 6:826-836(1992).
15489334	The MGC Project Team	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."	Genome Res. 14:2121-2127(2004).
1726837	Roghani M., Segovia B., Whitechurch O., Binoux M.	"Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species."	Growth Regul. 1:125-130(1991).
17020769	Kuang Z., Yao S., Keizer D.W., Wang C.C., Bach L.A., Forbes B.E., Wallace J.C., Norton R.S.	"Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)."	J. Mol. Biol. 364:690-704(2006).

Linked